Type 2 diabetic mouse model: improved insulin sensitivity; higher thermogenesis and respiratory exchange ratio; improved endurance indices
Qingyunshan TCM Innovation Science LaboratoryType 2 diabetic mice: each at half dose, the combination improved inflammation and myocardial fibrosis clearly more than either component alone at full dose; heart-injury markers came close to normal and the heart's pumping function improved
Test material Disugar® DNJ 5% · Qingyunshan TCM Innovation Science Laboratory · invention patent application published, CN 120789130 A · in the PCT international phaseEndothelial cell migration and mitochondrial membrane potential increased; after one month of dosing, type 2 diabetic mice showed more cerebral microvessel formation and higher cerebral blood perfusion, with open-field and novel-object recognition behaviour improving in parallel
Test material Disugar® DNJ 5% · Qingyunshan TCM Innovation R&D Co., Ltd. · invention patent application published, CN 120189455 A1.1% DNJ test material; single oral doses of 5,000 / 2,000 / 300 mg/kg in female SD rats; no deaths within 14 days
NMPA GLP-certified non-clinical drug evaluation centre · State Key Laboratory for New Drug Safety EvaluationInhibits both enzymes, with markedly stronger inhibition of α-glucosidase
China National Research Institute of Food and Fermentation Industries · Beijing Key Laboratory of Functional Staple Foods and Nutritional Intervention for Chronic DiseaseA single oral dose suppressed the postprandial rise in glucose and insulin
Kimura T. et al., J Agric Food Chem 2007;55:5869In type 2 diabetic and control subjects the rise in blood glucose after 75 g sucrose was smaller, while breath hydrogen rose — meaning part of the sucrose was not broken down and absorbed in the small intestine but passed to the colon for bacterial fermentation, independent evidence that sugar digestion was slowed
Mudra M. et al., Diabetes Care 2007;30:1272